Selective Binding and Reverse Transcription Inhibition of Single-Strand poly(A) RNA by Metal TMPyP Complexes

详细信息    查看全文

• 作者：Zhu-Xin Zhou ; Feng Gao ; Xing Chen ; Xiang-Jing Tian ; Liang-Nian Ji
• 刊名：Inorganic Chemistry
• 出版年：2014
• 出版时间：October 6, 2014
• 年：2014
• 卷：53
• 期：19
• 页码：10015-10017
• 全文大小：207K
• ISSN：1520-510X

文摘

Ni-, Cu-, and Zn-TMPyP are capable of binding to single-strand poly(A) RNA with high preference and affinity and inhibiting the reverse transcription of RNA by both M-MuLV and HIV-1 reverse transcriptase. With 10 nM azidothymidine, the IC₅₀ value of M-TMPyP could be lowered to 10^鈥? 渭M order.