Magnetic Prussian Blue Nanoparticles for Targeted Photothermal Therapy under Magnetic Resonance Imaging Guidance

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• 作者：Guanglei Fu ; Wei Liu ; Yanyan Li ; Yushen Jin ; Lingdong Jiang ; Xiaolong Liang ; Shanshan Feng ; Zhifei Dai
• 刊名：Bioconjugate Chemistry
• 出版年：2014
• 出版时间：September 17, 2014
• 年：2014
• 卷：25
• 期：9
• 页码：1655-1663
• 全文大小：562K
• ISSN：1520-4812

文摘

This paper reported a core鈥搒hell nanotheranostic agent by growing Prussian blue (PB) nanoshells of 3鈥? nm around superparamagnetic Fe₃O₄ nanocores for targeted photothermal therapy of cancer under magnetic resonance imaging (MRI) guidance. Both in vitro and in vivo experiments proved that the Fe₃O₄@PB core鈥搒hell nanoparticles showed significant contrast enhancement for T₂-weighted MRI with the relaxivity value of 58.9 mM^鈥?路s^鈥?. Simultaneously, the composite nanoparticles exhibited a high photothermal effect under irradiation of a near-infrared laser due to the strong absorption of PB nanoshells, which led to more than 80% death of HeLa cells with only 0.016 mg路mL^鈥? of the nanoparticles with the aid of the magnetic targeting effect. Using tumor-bearing nude mice as the model, the near-infrared laser light ablated the tumor effectively in the presence of the Fe₃O₄@PB nanoparticles and the tumor growth inhibition was evaluated to be 87.2%. Capabilities of MRI, magnetic targeting, and photothermal therapy were thus integrated into a single agent to allow efficient MRI-guided targeted photothermal therapy. Most importantly, both PB and Fe₃O₄ nanoparticles were already clinically approved drugs, so the Fe₃O₄@PB nanoparticles as a theranostic nanomedicine would be particularly promising for clinical applications in the human body due to the reliable biosafety.