Microwave Assisted Tandem Heck鈥揝onogashira Reactions of N,N-Di-Boc-Protected 6-Amino-5-iodo-2-methyl Pyrimidin-4-ol in An Efficient Approach to Functionalized Pyrido[2,3-d]Pyrimidines

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• 作者：Yang Liu ; Shiyu Jin ; Zi Wang ; Linhua Song ; Youhong Hu
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：July 3, 2014
• 年：2014
• 卷：16
• 期：13
• 页码：3524-3527
• 全文大小：340K
• ISSN：1523-7052

文摘

A microwave assisted tandem Heck鈥揝onogashira cross-coupling reaction between 6-N,N-di-Boc-amino-5-iodo-2-methyl pyrimidin-4-ol and various aryl alkynyl substrates has been developed. This process generates novel 5-enynyl substituted pyrimidines, which can be transformed to novel functionalized pyrido[2,3-d]pyrimidines by way of a silver catalyzed cyclization reaction.