Recent Advances in Developing Chemoenzymatic Processes for Active Pharmaceutical Ingredients

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• 作者：Junhua Tao ; Lishan Zhao ; Ningqing Ran
• 刊名：Organic Process Research & Development
• 出版年：2007
• 出版时间：March 2007
• 年：2007
• 卷：11
• 期：2
• 页码：259 - 267
• 全文大小：189K
• 年卷期：v.11,no.2(March 2007)
• ISSN：1520-586X

文摘

Biocatalysis is becoming a transformational technology forchemical synthesis as a result of recent advances in large-scaleDNA sequencing, structural biology, protein expression, highthroughput screening, and enzyme evolution technologies. Totruly impact chemical synthesis at the industrial scale, enzymediscovery, biocatalyst optimization, process design, and development must be integrated in order to deliver cost-effective andgreen chemistry solutions for drug manufacture. In this article,some recent applications of biocatalysis in developing chemoenzymatic processes were selected to illustrate the principle ofthis integrated approach. The emphasis will be directed to thoseexamples where the chemoenzymatic route represents a second-generation process developed to replace the existing chemicalone.