Improved Process for the Preparation of 1-Benzhydrylazetidin-3-ol: Development of an Efficient Synthesis and Identification of Process-related Impurities and/or Intermediates

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• 作者：V. V. R. M. Krishna Reddy ; K. Kishore Babu ; A. Ganesh ; P. Srinivasulu ; G. Madhusudhan ; K. Mukkanti
• 刊名：Organic Process Research & Development
• 出版年：2010
• 出版时间：July 16, 2010
• 年：2010
• 卷：14
• 期：4
• 页码：931-935
• 全文大小：201K
• 年卷期：v.14,no.4(July 16, 2010)
• ISSN：1520-586X

文摘

An improved, one-pot, and multikilogram-scale synthesis of 1-benzhydrylazetidin-3-ol, the pharmaceutically important moiety, has been developed. The improved process for the preparation of 1-benzhydrylazetidin-3-ol was able to minimize a content of impurities and allows the effective production of 1-benzhydrylazetidin-3-ol and its scale-up. The process was high yielding (80%) and chromatography-free with purity 99.3 area %.