Fully Automated Continuous Flow Synthesis of 4,5-Disubstituted Oxazoles

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• 作者：Marcus Baumann ; Ian R. Baxendale ; Steven V. Ley ; Christoper D. Smith ; Geoffrey K. Tranmer
• 刊名：Organic Letters
• 出版年：2006
• 出版时间：November 9, 2006
• 年：2006
• 卷：8
• 期：23
• 页码：5231 - 5234
• 全文大小：105K
• 年卷期：v.8,no.23(November 9, 2006)
• ISSN：1523-7052

文摘

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A multipurpose mesofluidic flow reactor capable of producing gram quantities of material has been developed as an automated synthesisplatform for the rapid on-demand synthesis of key building blocks and small exploratory libraries. The reactor is configured to provide themaximum flexibility for screening of reaction parameters that incorporate on-chip mixing and columns of solid supported reagents to expeditethe chemical syntheses.