Achieving 50% Ionization Efficiency in Subambient Pressure Ionization with Nanoelectrospray

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• 作者：Ioan Marginean ; Jason S. Page ; Aleksey V. Tolmachev ; Keqi Tang ; Richard D. Smith
• 刊名：Analytical Chemistry
• 出版年：2010
• 出版时间：November 15, 2010
• 年：2010
• 卷：82
• 期：22
• 页码：9344-9349
• 全文大小：285K
• 年卷期：v.82,no.22(November 15, 2010)
• ISSN：1520-6882

文摘

Inefficient ionization and poor transmission of the charged species produced by an electrospray from the ambient pressure mass spectrometer source into the high vacuum region required for mass analysis significantly limits achievable sensitivity. Here, we present evidence that, when operated at flow rates of 50 nL/min, a new electrospray-based ion source operated at 20 Torr can deliver 50% of the analyte ions initially in the solution as charged desolvated species into the rough vacuum region of mass spectrometers. The ion source can be tuned to optimize the analyte signal for readily ionized species while reducing the background contribution.