Conversion of Bromoalkenes into Alkynes by Wet Tetra-n-butylammonium Fluoride
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- 作者：Masaru Okutani ; Yuji Mori
- 刊名：Journal of Organic Chemistry
- 出版年：2009
- 出版时间：January 2, 2009
- 年：2009
- 卷：74
- 期：1
- 页码：442-444
- 全文大小：193K
- 年卷期：v.74,no.1(January 2, 2009)
- ISSN：1520-6904
文摘
Tetra-n-butylammonium fluoride was found to be a mild and efficient base for the elimination reaction of bromoalkenes. Treatment of 1,1-dibromoalkenes, (Z)-1-bromoalkenes, and internal bromoalkenes with 5 equiv of TBAF·3H2O in DMF yielded terminal and internal alkynes in high yields without undue regard to the presence of water.