In a two-component columnar host system composed of racemic (
rac)-1,2-diphenylethylenediamine and
rac-1,1'-binaphthyl-2,2'-dicarboxylicacid, a cavity tuning mechanism resulted from changes in the structure of the columns using a specific combination of the following fourmolecules: (1
R,2
R)-
1, (1
S,2
S)-
1, (
R)-
2, and (
S)-
2.