Enantioselective Arylative Cyclization of Allenyl Aldehydes with Arylboronic Acids under Pd(II)-diphosphine Catalysis

详细信息    查看全文

• 作者：Hirokazu Tsukamoto ; Tomotaka Matsumoto ; Yoshinori Kondo
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：March 20, 2008
• 年：2008
• 卷：10
• 期：6
• 页码：1047 - 1050
• 全文大小：119K
• 年卷期：v.10,no.6(March 20, 2008)
• ISSN：1523-7052

文摘

A Pd(OAc)₂-SEGPHOS combination catalyzes the first enantioselective arylative cyclization of allenyl aldehydes with arylboronic acids toprovide cis-fused five- and six-membered cyclic homoallylic alcohols. The excellent diastereo- and enantioselectivity and the fact that thereaction proceeds at room temperature in the absence of any additives make the process highly practical.