Design, Synthesis, and Biological Activity of a Family of Novel Ceramide Analogues in Chemoresistant Breast Cancer Cells
详细信息 查看全文
- 作者：James W. Antoon ; Jiawang Liu ; Matthew M. Gestaut ; Matthew E. Burow ; Barbara S. Beckman ; Maryam Foroozesh
- 刊名：Journal of Medicinal Chemistry
- 出版年：2009
- 出版时间：September 24, 2009
- 年：2009
- 卷：52
- 期：18
- 页码：5748-5752
- 全文大小：793K
- 年卷期：v.52,no.18(September 24, 2009)
- ISSN：1520-4804
文摘
Resistance to chemotherapy and endocrine therapy is a major cause of breast cancer treatment failure. We have synthesized six novel analogues using C8-ceramide as the lead analogue and studied their effect on hormone therapy resistant (MDA-MB-231) and chemoresistant (MCF-7TN-R) breast cancer cells. Pharmacologic intervention using these ceramide analogues inhibited clonogenic survival and induced apoptosis, with one analogue being more effective than C8-ceramide. Our results show ceramide-based therapy has therapeutic potential in treating drug resistant breast cancer.