The Lecanindoles, Nonsteroidal Progestins from the Terrestrial Fungus Verticillium lecanii 6144

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• 作者：Deborah M. Roll ; Laurel R. Barbieri ; Ramunas Bigelis ; Leonard A. McDonald ; Daniel A. Arias ; Li-Ping Chang ; Maya P. Singh ; Scott W. Luckman ; Thomas J. Berrodin ; Matthew R. Yudt
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：November 30, 2009
• 年：2009
• 卷：72
• 期：11
• 页码：1944-1948
• 全文大小：154K
• 年卷期：v.72,no.11(November 30, 2009)
• ISSN：1520-6025

文摘

Four new indolosesquiterpenes, lecanindoles A−D (1−4), were isolated from fermentations of the terrestrial fungus Verticillium lecanii 6144. The structures of compounds 1−4 were elucidated from analysis of spectroscopic data. Compound 2 was reduced to give 4 and its isomer 5. Compound 4 was found to be a potent and selective progesterone receptor agonist with an EC₅₀ of 1.1 ± 0.4 nM in a cell-based luciferase reporter assay.