Bioactive ent-Pimarane and ent-Abietane Diterpenoids from the Whole Plants of Chloranthus henryi

详细信息    查看全文

• 作者：Chunfeng Xie ; Lingmei Sun ; Kai Liao ; Sheng Liu ; Meicheng Wang ; Jing Xu ; Mark Bartlam ; Yuanqiang Guo
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：November 25, 2015
• 年：2015
• 卷：78
• 期：11
• 页码：2800-2807
• 全文大小：420K
• ISSN：1520-6025

文摘

Two new ent-pimarane (1 and 2), eight new ent-abietane (3鈥?b>10) diterpenoids, and eight known analogues (11鈥?b>18) were isolated from the whole plants of Chloranthus henryi. The absolute configuration of 1 was determined on the basis of single-crystal X-ray diffraction data. Compound 8 represents a class of rare naturally occurring C-14 norabietanes, and compounds 9 and 10 feature rare 13,14-seco-abietane skeletons. Compounds 5, 12, 13, and 15 inhibited the yeast-to-hyphae transition of Candida albicans with IC₅₀ values between 97.3 and 738.7 渭M.