Design, Synthesis, and Evaluation of Naphthalene-Sulfonamide Antagonists of Human CCR8
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- 作者：Tracy J. Jenkins ; Bing Guan ; Mingshi Dai ; Gang Li ; Thomas E. Lightburn ; Shan Huang ; B. Scott Freeze ; Douglas F. Burdi ; Swanee Jacutin-Porte ; Robert Bennett ; Weirong Chen ; Charles Minor ; Shomir Ghosh
- 刊名：Journal of Medicinal Chemistry
- 出版年：2007
- 出版时间：February 8, 2007
- 年：2007
- 卷：50
- 期：3
- 页码：566 - 584
- 全文大小：299K
- 年卷期：v.50,no.3(February 8, 2007)
- ISSN：1520-4804
文摘
The design, synthesis, and structure-activity relationship development of naphthalene-derived human CCR8antagonists is described. In vitro binding assay results of these investigations are reported, critical interactionsof the antagonists with CCR8 are defined, and preliminary physicochemical and pharmacokinetic data forthe naphthalene scaffold are presented.