Polystyrene-Supported (2S)-(鈭?-3-exo-Piperazinoisoborneol: An Efficient Catalyst for the Batch and Continuous Flow Production of Enantiopure Alcohols

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• 作者：Laura Osorio-Planes ; Carles Rodr铆guez-Escrich ; Miquel A. Peric脿s
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：April 6, 2012
• 年：2012
• 卷：14
• 期：7
• 页码：1816-1819
• 全文大小：251K
• 年卷期：v.14,no.7(April 6, 2012)
• ISSN：1523-7052

文摘

A polystyrene-supported analog (PS-PIB) of 3-exo-morpholinoisoborneol (MIB), designed for increased chemical stability, has been synthesized and used as a ligand in the asymmetric alkylation of aldehydes with Et<sub>2sub>Zn. The supported ligand turned out to be highly active and enantioselective for a broad scope of substrates (92鈥?9% ee), allowing repeated recycling. A single-pass, continuous flow process implemented with PS-PIB shows only a marginal decrease in conversion after 30 h of operation.