Nonmetathesis Heterocycle Formation by Ruthenium-Catalyzed Intramolecular [2 + 2] Cycloaddition of Allenamide-enes to Azabicyclo[3.1.1]heptanes

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• 作者：Tomomi Nada ; Yusuke Yoneshige ; Yasuhiro Ii ; Takashi Matsumoto ; Hiromichi Fujioka ; Satoshi Shuto ; Mitsuhiro Arisawa
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：6
• 期：5
• 页码：3168-3171
• 全文大小：424K
• 年卷期：0
• ISSN：2155-5435

文摘

We have developed a novel nonmetathesis reaction, namely, ruthenium-catalyzed intramolecular [2 + 2] cycloaddition of allenamide-enes, to give heterocycles (i.e., azabicyclo[3.1.1]heptanes). This is the first example of [2 + 2] cycloaddition using a ruthenium carbene catalyst. The reaction proceeds at room temperature, but not under thermal or radical conditions.