Asymmetric Synthesis and Absolute Configuration of Streptophenazine G

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• 作者：Zhicai Yang ; Xiaomin Jin ; Michael Guaciaro ; Bruce F. Molino
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：April 6, 2012
• 年：2012
• 卷：77
• 期：7
• 页码：3191-3196
• 全文大小：283K
• 年卷期：v.77,no.7(April 6, 2012)
• ISSN：1520-6904

文摘

The asymmetric synthesis of the antibacterial natural product, streptophenazine G, has been achieved by employing asymmetric alkylation and asymmetric aldol reactions using chiral oxazolidinones as the key steps. The originally proposed structure for streptophenazine G has been revised, and its absolute configuration has been determined to be 1鈥?i>S,2鈥?i>R,6鈥?i>S. The asymmetric total synthesis of 6鈥?epi-streptophenazine G is also described.