Perennisosides I−VII, Acylated Triterpene Saponins with Antihyperlipidemic Activities from the Flowers of Bellis perennis

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• 作者：Toshio Morikawa ; Xuezheng Li ; Eriko Nishida ; Yuki Ito ; Hisashi Matsuda ; Seikou Nakamura ; Osamu Muraoka ; Masayuki Yoshikawa
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：May 2008
• 年：2008
• 卷：71
• 期：5
• 页码：828 - 835
• 全文大小：119K
• 年卷期：v.71,no.5(May 2008)
• ISSN：1520-6025

文摘

The methanolic extract and its saponin fraction (methanol-eluted fraction) of the flowers of Bellis perennis were found to suppress serum triglyceride elevation in olive oil-treated mice. From the saponin fraction, seven new triterpene saponins, perennisosides I (1), II (2), III (3), IV (4), V (5), VI (6), and VII (7), were isolated together with four known saponins, bellidioside A (8), asterbatanoside D (9), bernardioside B₂ (10), and bellissaponin BS6 (11). The stereostructures of 1−7 were elucidated on the basis of chemical and spectroscopic evidence. Among these saponins, perennisosides I (1) and II (2) showed inhibitory effects on serum triglyceride elevation at doses of 25−50 mg/kg, po.