On the Effect of Temperature on Aqueous Solubility of Organic Solids

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• 作者：Simon Black ; Frans Muller
• 刊名：Organic Process Research & Development
• 出版年：2010
• 出版时间：May 21, 2010
• 年：2010
• 卷：14
• 期：3
• 页码：661-665
• 全文大小：184K
• 年卷期：v.14,no.3(May 21, 2010)
• ISSN：1520-586X

文摘

The variation of solubility with temperature in water is an important consideration in the design of crystallizations and other processes. Solubility was found to vary exponentially with temperature (in °C) for a literature data set of 50 organic molecules in water. This complements a similar recent finding for the solubility of organic molecules in organic solvents. The ‘solubility doubling temperature’ is a convenient way to express this variation and provides a numerical link between enthalpy of dissolution and yield. The ‘solubility doubling temperature’ in water varies with solute, and the median value from this data set is 21.4 °C, consistent with ‘Black’s rule’.