An Alternative Method to Isolate Pharmaceutical Intermediates

详细信息    查看全文

• 作者：Frans L. Muller ; Brian Whitlock
• 刊名：Organic Process Research & Development
• 出版年：2011
• 出版时间：January 21, 2011
• 年：2011
• 卷：15
• 期：1
• 页码：84-90
• 全文大小：434K
• 年卷期：v.15,no.1(January 21, 2011)
• ISSN：1520-586X

文摘

A robust crystallisation process can be resource intensive to develop, but simpler isolation alternatives such as evaporation to dryness can have thermal stability issues and result in a difficult to handle solid residue. This contribution presents Solid Supported Evaporation as an equally simple alternative to evaporation to dryness but which goes some way to overcome the thermal stability issue and results in an easy to handle solid product.