Development of a Vitreous Substitute: Incorporating Charges and Fibrous Structures in Synthetic Hydrogel Materials

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• 作者：Svetlana Morozova ; Paul Hamilton ; Nathan Ravi ; Murugappan Muthukumar
• 刊名：Macromolecules
• 出版年：2016
• 出版时间：June 28, 2016
• 年：2016
• 卷：49
• 期：12
• 页码：4619-4626
• 全文大小：410K
• 年卷期：0
• ISSN：1520-5835

文摘

Synthetic hydrogel systems are promising long-term candidates for therapeutic use as vitreous substitutes. To improve the swelling and mechanical properties of existing synthetic substitutes for the natural vitreous, we incorporate charges and fibrous structures. Using dynamic light scattering, rheology, and swelling techniques we show in vitro that synthetic copolymers of methacrylic acid (MAA), methylacrylamide (MAm), and bismethacryloylcystamine (BMAC) cross-linked with gellan match the water content, transport properties, and dynamic response of the natural vitreous better than previously proposed synthetic substitutes.