Bioactive 1,4-Dihydroxy-5-phenyl-2-pyridinone Alkaloids from Septoria pistaciarum
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- 作者：Mallika Kumarihamy ; Frank R. Fronczek ; Daneel Ferreira ; Melissa Jacob ; Shabana I. Khan ; N. P. Dhammika Nanayakkara
- 刊名：Journal of Natural Products
- 出版年：2010
- 出版时间：July 23, 2010
- 年：2010
- 卷：73
- 期：7
- 页码：1250-1253
- 全文大小：149K
- 年卷期：v.73,no.7(July 23, 2010)
- ISSN：1520-6025
文摘
Four new 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids (1−4) were isolated from an EtOAc extract of a culture medium of Septoria pistaciarum. The structures of these compounds were determined by spectroscopic methods, and the absolute configuration of the major compound (1) was determined by X-ray crystallographic analysis. Compound 1 exhibited moderate in vitro antiplasmodial (antimalarial) activity against chloroquine-sensitive (D6) and -resistant (W2) strains of Plasmodium falciparum and cytotoxic activity to Vero cells. Compound 2 was moderately active against both methicillin-sensitive and methicillin-resistant strains of Staphylococcus aureus.