Photoassisted Access to Enantiopure Conformationally Locked Ribofuranosylamines Spiro-Linked to Oxazolidino-Diketopiperazines.
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- 作者：Nitin S. Nandurkar ; N. N. Bhuvan Kumar ; Olga A. Mukhina ; Andrei G. Kutateladze
- 刊名：ACS Combinatorial Science
- 出版年：2013
- 出版时间：January 14, 2013
- 年：2013
- 卷：15
- 期：1
- 页码：73-76
- 全文大小：286K
- 年卷期：v.15,no.1(January 14, 2013)
- ISSN：2156-8944
文摘
N-Furoylated <span class="smallcaps">lspan>-threonine-, serine-, or cysteine-based aminoacetals are coupled with o-aminoketones or aldehydes to offer rapid access to diverse enantiopure polyheterocycles possessing conformationally locked aminoglycoside-containing molecular scaffolds. The key step involves photogeneration of azaxylylenes which undergo [4 + 4] or [4 + 2] cycloadditions to the tethered furoyl pendants.