Effect of Additives on Crystal Growth and Nucleation of Amorphous Flutamide

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• 作者：Niraj S. Trasi ; Lynne S. Taylor
• 刊名：Crystal Growth & Design
• 出版年：2012
• 出版时间：June 6, 2012
• 年：2012
• 卷：12
• 期：6
• 页码：3221-3230
• 全文大小：425K
• 年卷期：v.12,no.6(June 6, 2012)
• ISSN：1528-7505

文摘

Understanding the effect of polymers on the crystallization behavior of low molecular weight organic compounds is important to a number of areas. Since crystallization is a combination of nucleation and growth, it is of interest to evaluate how these additives influence both these processes. In this study, the crystallization of supercooled liquid flutamide in the presence and absence of a number of synthetic vinyl polymers with different functional groups was investigated, at a constant molar ratio of polymer functional group. The impact of a structurally similar small molecule compound, nilutamide, was also evaluated. Isothermal crystal growth rates were measured using hot stage microscopy, while nucleation behavior was more qualitatively investigated using differential scanning calorimetry. Polymers that formed better hydrogen bonds via their acceptor groups, as determined by infrared spectroscopy, were found to be more effective at reducing crystal growth rates, while nilutamide influenced growth rates mostly by increasing the blend glass transition temperature. Only two polymers had a noticeable impact on nucleation behavior, while nilutamide was by far the most effective at reducing nucleation rates, most likely due to its low molecular size. This study has further highlighted the correlation between drug鈥損olymer hydrogen bonding interactions and crystal growth, and the corresponding lack of correlation between this factor and nucleation behavior.