Relaxometric and Magnetic Characterization of Ultrasmall Iron Oxide Nanoparticles with High Magnetization. Evaluation as Potential T1 Magnetic Resonance Imaging Contrast Agents for M
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- 作者：Elena Taboada ; Elisenda Rodrí ; guez ; Anna Roig ; Judit Oró ; Alain Roch ; Robert N. Muller
- 刊名：Langmuir
- 出版年：2007
- 出版时间：April 10, 2007
- 年：2007
- 卷：23
- 期：8
- 页码：4583 - 4588
- 全文大小：368K
- 年卷期：v.23,no.8(April 10, 2007)
- ISSN：1520-5827
文摘
Here we report on the synthesis of ultrasmall 
-Fe2O3 nanoparticles (5 nm) presenting a very narrow particle sizedistribution and an exceptionally high saturation magnetization. The synthesis has been carried out by decompositionof an iron organometallic precursor in an organic medium. The particles were subsequently stabilized in an aqueoussolution at physiological pH, and the colloidal dispersions have been thoroughly characterized by complementarytechniques. Particular attention has been given to the assessment of the mean particle size by transmission electronmicroscopy, X-ray diffraction, dynamic light scattering, magnetic, and relaxometric measurements. The good agreementfound between the different techniques points to a very narrow particle size distribution. Regarding the magneticproperties, the particles are superparamagnetic at room temperature and present an unusually high saturation magnetizationvalue. In addition, we describe the potential of these particles as specific positive contrast agents for magnetic resonancemolecular imaging.
-Fe2O3 nanoparticles (5 nm) presenting a very narrow particle sizedistribution and an exceptionally high saturation magnetization. The synthesis has been carried out by decompositionof an iron organometallic precursor in an organic medium. The particles were subsequently stabilized in an aqueoussolution at physiological pH, and the colloidal dispersions have been thoroughly characterized by complementarytechniques. Particular attention has been given to the assessment of the mean particle size by transmission electronmicroscopy, X-ray diffraction, dynamic light scattering, magnetic, and relaxometric measurements. The good agreementfound between the different techniques points to a very narrow particle size distribution. Regarding the magneticproperties, the particles are superparamagnetic at room temperature and present an unusually high saturation magnetizationvalue. In addition, we describe the potential of these particles as specific positive contrast agents for magnetic resonancemolecular imaging.