Water-Soluble Tb3+ and Eu3+ Complexes with Ionophilic (Ionically Tagged) Ligands as Fluorescence Imaging Probes

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• 作者：Julia R. Diniz ; Jos茅 R. Correa ; Daniel de A. Moreira ; Rafaela S. Fontenele ; Aline L. de Oliveira ; Patr铆cia V. Abdelnur ; Jos茅 D. L. Dutra ; Ricardo O. Freire ; Marcelo O. Rodrigues ; Brenno A. D. Neto
• 刊名：Inorganic Chemistry
• 出版年：2013
• 出版时间：September 3, 2013
• 年：2013
• 卷：52
• 期：17
• 页码：10199-10205
• 全文大小：377K
• 年卷期：v.52,no.17(September 3, 2013)
• ISSN：1520-510X

文摘

This article describes a straightforward and simple synthesis of ionically tagged water-soluble Eu³⁺ and Tb³⁺ complexes (with ionophilic ligands) applied for bioimaging of invasive mammal cancer cells (MDA-MB-231). Use of the task-specific ionic liquid 1-methyl-3-carboxymethyl-imidazolium chloride (MAI路Cl) as the ionophilic ligand (ionically tagged) proved to be a simple, elegant, and efficient strategy to obtain highly fluorescent water-soluble Eu³⁺ (EuMAI) and Tb³⁺ (TbMAI) complexes. TbMAI showed an intense bright green fluorescence emission selectively staining endoplasmic reticulum of MDA-MB-231 cells.