Synthesis of β-Hydroxysulfones from Sulfonyl Chlorides and Alkenes Utilizing Visible Light Photocatalytic Sequences

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• 作者：Santosh K. Pagire ; Suva Paria ; Oliver Reiser
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：18
• 期：9
• 页码：2106-2109
• 全文大小：405K
• 年卷期：0
• ISSN：1523-7052

文摘

The synthesis of β-hydroxysulfones from sulfonyl chlorides and styrenes in the presence of water by a visible light mediated atom transfer radical addition (ATRA)-like process utilizing fac[Ir(ppy)₃] as photoredox catalyst was developed in high yields. This process could be combined with the visible light mediated synthesis of trifluoromethylated sulfonyl chlorides via an ATRA reaction between alkenes and CF₃SO₂Cl utilizing [Cu(dap)₂Cl] as photoredox catalyst, demonstrating the possibility of sequential photoredox processes.