Intramolecular Acylation of Unactivated Pyridines or Arenes via Multiple C–H Functionalizations: Synthesis of All Four Azafluorenones and Fluorenones
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- 作者：Joydev K. LahaKrupal P. Jethava ; Sagarkumar Patel ; Ketul V. Patel
- 刊名：Journal of Organic Chemistry
- 出版年：2017
- 出版时间：January 6, 2017
- 年：2017
- 卷：82
- 期：1
- 页码：76-85
- 全文大小：558K
- ISSN：1520-6904
文摘
An unprecedented intramolecular acylation of unactivated pyridines via multiple C(sp3/sp2)–H functionalizations of a methyl, hydroxymethyl, or aldehyde group has been developed providing a general access to all four azafluorenones. The application of this protocol is further demonstrated to the synthesis of azafluorenone related fused nitrogen heterocycles and fluorenones. In addition, design and synthesis of a novel fluorene based organic emitter for potential use in organic light emitting devices (OLEDs) is also reported.