Cupric Superoxo-Mediated Intermolecular C鈭扝 Activation Chemistry

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• 作者：Ryan L. Peterson ; Richard A. Himes ; Hiroaki Kotani ; Tomoyoshi Suenobu ; Li Tian ; Maxime A. Siegler ; Edward I. Solomon ; Shunichi Fukuzumi ; Kenneth D. Karlin
• 刊名：Journal of the American Chemical Society
• 出版年：2011
• 出版时间：February 16, 2011
• 年：2011
• 卷：133
• 期：6
• 页码：1702-1705
• 全文大小：764K
• 年卷期：v.133,no.6(February 16, 2011)
• ISSN：1520-5126

文摘

The new cupric superoxo complex [LCu^II(O₂^鈥⑩垝)]⁺, which possesses particularly strong O鈭扥 and Cu鈭扥 bonding, is capable of intermolecular C鈭扝 activation of the NADH analogue 1-benzyl-1,4-dihydronicotinamide (BNAH). Kinetic studies indicated a first-order dependence on both the Cu complex and BNAH with a deuterium kinetic isotope effect (KIE) of 12.1, similar to that observed for certain copper monooxygenases.