Synthesis of Protected (1-Phenyl-1H-pyrrol-2-yl)-alkane-1-amines from Phenylnitroso Diels鈥揂lder Adducts with 1,2-Dihydropyridines

详细信息    查看全文

• 作者：Francesco Berti ; Valeria Di Bussolo ; Mauro Pineschi
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：July 19, 2013
• 年：2013
• 卷：78
• 期：14
• 页码：7324-7329
• 全文大小：263K
• 年卷期：v.78,no.14(July 19, 2013)
• ISSN：1520-6904

文摘

The reductive cleavage of nitrosobenzene-derived cycloadducts with appropriately protected 1,2-dihydropyridines allows a novel and simple obtainment of substituted N-[1-(1-phenyl-1H-pyrrol-2-yl)alkylamides. This synthesis can also be carried out in a very simple, mild, and practical one-pot procedure without isolation of the corresponding nitrosobenzene cycloadduct by means of catalytic amounts of CuCl.