Palladium(II)-Catalyzed C鈥揌 Bond Activation/C鈥揅 Coupling/Intramolecular Tsuji鈥揟rost Reaction Cascade: Facile Access to 2H-Pyranonaphthoquinones

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• 作者：Jinlei Bian ; Xue Qian ; Nan Wang ; Tong Mu ; Xiang Li ; Haopeng Sun ; Lianshan Zhang ; Qidong You ; Xiaojin Zhang
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：July 17, 2015
• 年：2015
• 卷：17
• 期：14
• 页码：3410-3413
• 全文大小：295K
• ISSN：1523-7052

文摘

An efficient one-pot synthesis of 2H-pyranonaphthoquinone was achieved via a palladium-catalyzed C鈥揌 bond activation/C鈥揅 bond formation/intramolecular Tsuji鈥揟rost reaction cascade. The unprecedented procedure exhibits excellent functional group tolerance, giving the target naphthoquinones in moderate to good isolated yields (40鈥?8%) under mild reaction conditions. Scalable production of the product can make this reaction a method of choice for the synthesis of 2H-pyranonaphthoquinones.