Supramolecular Architectures of Dendritic Amphiphiles in Water

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• 作者：Bala N. S. Thota ; Leonhard H. Urner ; Rainer Haag
• 刊名：Chemical Reviews
• 出版年：2016
• 出版时间：February 24, 2016
• 年：2016
• 卷：116
• 期：4
• 页码：2079-2102
• 全文大小：1725K
• 年卷期：
  Dr. Bala N. S. Thota received his Ph.D. from the Department of Organic Chemistry, Indian Institute of Science, Bangalore, under the supervision of Prof. Uday Maitra. The focus of his thesis was on the synthesis and aggregation properties of bile acid derived oligomers. He is currently a postdoctoral fellow in the group of Prof. Rainer Haag and working on engineering self-assembled nanostructures using dendritic amphiphiles. His research interests are self-assembly of amphiphilic molecules and development of novel drug delivery systems.
  Leonhard H. Urner received his Master of Science degree in Chemistry from the Freie Universität Berlin, Germany, in 2015. He is currently working with Prof. Kevin Pagel and Prof. Rainer Haag on his Ph.D. His research interest is mainly focused on synthesis and investigation of dendritic azobenzene-based amphiphiles in solution and gas phase.
  Prof. Dr. Rainer Haag obtained his Ph.D. with A. de Meijere at the University of Göttingen in 1995. After postdoctoral work with S. V. Ley, University of Cambridge (U.K.), and G. M. Whitesides, Harvard University, Cambridge, MA (U.S.A.), he completed his habilitation at the University of Freiburg in 2002. He then became associate professor at the University of Dortmund and in 2004 was appointed full Professor of Organic and Macromolecular Chemistry at the Freie Universität Berlin. One of his main research interests is the mimicry of biological systems by functional dendritic polymers, with particular focus on applications in nanomedicine.
• ISSN：1520-6890

文摘

Dendritic molecules are an exciting research topic because of their highly branched architecture, multiple functional groups on the periphery, and very pertinent features for various applications. Self-assembling dendritic amphiphiles have produced different nanostructures with unique morphologies and properties. Since their self-assembly in water is greatly relevant for biomedical applications, researchers have been looking for a way to rationally design dendritic amphiphiles for the last few decades. We review here some recent developments from investigations on the self-assembly of dendritic amphiphiles into various nanostructures in water on the molecular level. The main content of the review is divided into sections according to the different nanostructure morphologies resulting from the dendritic amphiphiles’ self-assembly. Finally, we conclude with some remarks that highlight the self-assembling features of these dendritic amphiphiles.