Pathogen Inhibition by Multivalent Ligand Architectures

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• 作者：Sumati Bhatia ; Luis Cuellar Camacho ; Rainer Haag
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：July 20, 2016
• 年：2016
• 卷：138
• 期：28
• 页码：8654-8666
• 全文大小：770K
• 年卷期：0
• ISSN：1520-5126

文摘

Interfacial multivalent interactions at pathogen–cell interfaces can be competitively inhibited by multivalent scaffolds that prevent pathogen adhesion to the cells during the initial stages of infection. The lack of understanding of complex biological systems makes the design of an efficient multivalent inhibitor a toilsome task. Therefore, we have highlighted the main issues and concerns associated with blocking pathogen at interfaces, which are dependent on the nature and properties of both multivalent inhibitors and pathogens, such as viruses and bacteria. The challenges associated with different cores or carrier scaffolds of multivalent inhibitors are concisely discussed with selected examples.