Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4-b]quinoline Hybrid Heterocycles
详细信息 查看全文
- 作者：Remani Vasudevan Sumesh ; Muthumani Muthu ; Abdulrahman I. Almansour ; Raju Suresh Kumar ; Natarajan Arumugam ; S. Athimoolam ; E. Arockia Jeya Yasmi Prabha ; Raju Ranjith Kumar
- 刊名：ACS Combinatorial Science
- 出版年：2016
- 出版时间：May 9, 2016
- 年：2016
- 卷：18
- 期：5
- 页码：262-270
- 全文大小：644K
- 年卷期：0
- ISSN：2156-8944
文摘
The stereoselective syntheses of a library of novel spiro-tethered pyrazolo[3,4-b]quinoline–pyrrolidine/pyrrolothiazole/indolizine–oxindole/acenaphthene hybrid heterocycles have been achieved through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ from α-amino acids and 1,2-diketones to dipolarophiles derived from pyrazolo[3,4-b]quinoline derivatives.