An Improved and Scalable Process for the Synthesis of 5-Azacytidine: An Antineoplastic Drug

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• 作者：Satish Kumar Vujjini ; Ganesh Varanasi ; Srinivas Arevelli ; Sreenatha Charyulu Kandala ; Satyanarayana Raju Tirumalaraju ; Rakeshwar Bandichhor ; Mukkanti Kagga ; Praveen Cherukupally
• 刊名：Organic Process Research & Development
• 出版年：2013
• 出版时间：February 15, 2013
• 年：2013
• 卷：17
• 期：2
• 页码：303-306
• 全文大小：187K
• 年卷期：v.17,no.2(February 15, 2013)
• ISSN：1520-586X

文摘

An improved, practical, and scalable process for the manufacture of antineoplastic drug, 5-azacytidine (1), is described. A thorough understanding of the reaction parameters and stability of the reaction intermediates led us to the development of a robust process. The challenges in the isolation and systematic approach used to streamline the process into a very robust and practical manufacturing process are described.