Nickel-Catalyzed Direct C (sp3)鈥揌 Arylation of Aliphatic Amides with Thiophenes
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- 作者：Xie Wang ; Longzhi Zhu ; Sihai Chen ; Xinhua Xu ; Chak-Tong Au ; Renhua Qiu
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：November 6, 2015
- 年：2015
- 卷：17
- 期：21
- 页码：5228-5231
- 全文大小：356K
- ISSN：1523-7052
文摘
Nickel-catalyzed heteroarylation of the inactive methyl C(sp3)鈥揌 bond of aliphatic amide with heteroarenes is described. The method takes advantage of chelation assistance by an 8-aminoquinolinyl moiety. The synthetic reaction has good tolerance toward functional groups, and it can be used in the construction of various kinds of alkyl-substituted heteroarenes.