Aryldiazonium Tetrafluoroborate Salts as Green and Efficient Coupling Partners for the Suzuki鈥揗iyaura Reaction: From Optimisation to Mole Scale
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- 作者：Aymeric P. Colleville ; Richard A. J. Horan ; Nicholas C. O. Tomkinson
- 刊名：Organic Process Research & Development
- 出版年：2014
- 出版时间：September 19, 2014
- 年：2014
- 卷：18
- 期：9
- 页码：1128-1136
- 全文大小：428K
- ISSN：1520-586X
文摘
The use of aryldiazonium tetrafluoroborate salts as coupling partners in the Suzuki鈥揗iyaura reaction was investigated from a process chemistry perspective including safety evaluation, solvent and catalyst screening and multivariate factor optimisation. Optimised conditions were applied to a range of substrates to evaluate the scope and limitations of the reaction, and one example was carried out on mole scale to demonstrate the practicality and scalability of the process.