Structural Properties of Pore-Forming Oligomers of α-Synuclein

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• 作者：Hai-Young Kim ; Min-Kyu Cho ; Ashutosh Kumar ; Elke Maier ; Carsten Siebenhaar ; Stefan Becker ; Claudio O. Fernandez ; Hilal A. Lashuel ; Roland Benz ; Adam Lange ; Markus Zweckstetter
• 刊名：Journal of the American Chemical Society
• 出版年：2009
• 出版时间：December 2, 2009
• 年：2009
• 卷：131
• 期：47
• 页码：17482-17489
• 全文大小：407K
• 年卷期：v.131,no.47(December 2, 2009)
• ISSN：1520-5126

文摘

Soluble oligomers are potent toxins in many neurodegenerative diseases, but little is known about the structure of soluble oligomers and their structure−toxicity relationship. Here we prepared on-pathway oligomers of the 140-residue protein α-synuclein, a key player in Parkinson’s disease, at concentrations an order of magnitude higher than previously possible. The oligomers form ion channels with well-defined conductance states in a variety of membranes, and their β-structure differs from that of amyloid fibrils of α-synuclein.