Syntheses of trans-SCH-A and cis-SCH-A via a Stereodivergent Cyclopropanation Protocol

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• 作者：Kristna Csatayov ; Stephen G. Davies ; James A. Lee ; Kenneth B. Ling ; Paul M. Roberts ; Angela J. Russell ; James E. Thomson
• 刊名：Organic Letters
• 出版年：2010
• 出版时间：July 16, 2010
• 年：2010
• 卷：12
• 期：14
• 页码：3152-3155
• 全文大小：221K
• 年卷期：v.12,no.14(July 16, 2010)
• ISSN：1523-7052

文摘

A highly diastereoselective cyclopropanation protocol has been employed in the syntheses of trans-SCH-A and cis-SCH-A. This strategy encompasses a stereodivergent procedure for the preparation of syn- and anti-cyclopropane diastereoisomers in high dr from a common allylic carbamate precursor.