Toward the Racemic Total Synthesis of Hederacines A and B: Construction of an Advanced Tricyclic Intermediate

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• 作者：Miho Yamashita ; Tetsuya Yamashita ; Sakae Aoyagi
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：May 6, 2011
• 年：2011
• 卷：13
• 期：9
• 页码：2204-2207
• 全文大小：820K
• 年卷期：v.13,no.9(May 6, 2011)
• ISSN：1523-7052

文摘

Progress toward the total synthesis of hederacines A and B is described. Our approach involves an allylic cyanate-to-isocyanate rearrangement, eneyne ring-closing metathesis, and a transannular reaction between the C-5 amino group and the C-12 position of the perhydroazuleno[5,6-b]furanone intermediate.