A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries

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• 作者：Marc A. Giulianotti ; Ginamarie Debevec ; Radleigh G. Santos ; Laura E. Maida ; Wenteng Chen ; Lili Ou ; Yongping Yu ; Colette T. Dooley ; Richard A. Houghten
• 刊名：ACS Combinatorial Science
• 出版年：2012
• 出版时间：September 10, 2012
• 年：2012
• 卷：14
• 期：9
• 页码：503-512
• 全文大小：564K
• 年卷期：v.14,no.9(September 10, 2012)
• ISSN：2156-8944

文摘

A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed.

Keywords:

g/action/doSearch?action=search&searchText=positional+scanning+library&qsSearchArea=searchText">positional scanning library; g/action/doSearch?action=search&searchText=isokinetic+ratios&qsSearchArea=searchText">isokinetic ratios; g/action/doSearch?action=search&searchText=combinatorial+libraries&qsSearchArea=searchText">combinatorial libraries; g/action/doSearch?action=search&searchText=harmonic+mean&qsSearchArea=searchText">harmonic mean; g/action/doSearch?action=search&searchText=piperazine&qsSearchArea=searchText">piperazine; g/action/doSearch?action=search&searchText=sulfonamide&qsSearchArea=searchText">sulfonamide; g/action/doSearch?action=search&searchText=guanidine&qsSearchArea=searchText">guanidine