Thermo-Induced Aggregation and Crystallization of Block Copolypeptoids in Water

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• 作者：Christian Secker ; Antje V?lkel ; Brigitte Tiersch ; Joachim Koetz ; Helmut Schlaad
• 刊名：Macromolecules
• 出版年：2016
• 出版时间：February 9, 2016
• 年：2016
• 卷：49
• 期：3
• 页码：979-985
• 全文大小：432K
• ISSN：1520-5835

文摘

Block copolypeptoids comprising a thermosensitive, crystallizable poly(N-(n-propyl)glycine) block and a water-soluble poly(N-methylglycine) block, P₇₀M_y (y = 23, 42, 76, 153, and 290), were synthesized by ring-opening polymerization of the corresponding N-alkylglycine N-carboxyanhydrides (NCAs) and examined according to their thermo-induced aggregation and crystallization in water by turbidimetry, micro-differential scanning calorimetry (micro-DSC), cryogenic scanning electron microscopy (cryo-SEM), analytical ultracentrifugation (AUC), and static light scattering (SLS). At a temperature above the cloud point temperature, the initially formed micellar aggregates started to crystallize and grow into larger complex assemblies of about 100–500 nm, exhibiting flower-like (P₇₀M₂₃), ellipsoidal (P₇₀M₄₂ and P₇₀M₇₂), or irregular shapes (P₇₀M₁₅₃ and P₇₀M₂₉₀).