Design and Comparison of Tubular and Pipes-in-Series Continuous Reactors for Direct Asymmetric Reductive Amination

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• 作者：Martin D. Johnson ; Scott A. May ; Brian Haeberle ; Gordon R. Lambertus ; Shon R. Pulley ; James R. Stout
• 刊名：Organic Process Research & Development
• 出版年：2016
• 出版时间：July 15, 2016
• 年：2016
• 卷：20
• 期：7
• 页码：1305-1320
• 全文大小：577K
• 年卷期：0
• ISSN：1520-586X

文摘

A high pressure, high temperature direct asymmetric reductive amination (DARA) reaction was run in three different continuous reactor types; coiled tubes, horizontal pipes in series, and vertical pipes in series. The goal of this work was to design a continuous reactor scalable to large volumes needed for commercial scale manufacturing. With about 4000:1 substrate to dissolved catalyst ratio, the DARA reaction achieved about 90% conversion to desired product in 12 h, about 8% conversion to undesired ketone, and about 95% ee, in batch and in all 3 types of continuous reactors. The 3 continuous reactors were compared on the basis of vapor/liquid mass transfer rates, overall pressure drop, and axial dispersion. Vertical pipes in series were selected as the best option because of scalability and vapor/liquid mass transfer rates, although horizontal pipes had lower pressure drop and less potential for surging.