Comparison of the Cardiac MicroPET Images Obtained Using [18F]FPTP and [13N]NH3 in Rat Myocardial Infarction Models

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• 作者：Dong-Yeon Kim ; Hyeon Sik Kim ; Hwa Youn Jang ; Ju Han Kim ; Hee-Seung Bom ; Jung-Joon Min
• 刊名：ACS Medicinal Chemistry Letters
• 出版年：2014
• 出版时间：October 9, 2014
• 年：2014
• 卷：5
• 期：10
• 页码：1124-1128
• 全文大小：261K
• ISSN：1948-5875

文摘

The short half-life of current positron emission tomography (PET) cardiac tracers limits their widespread clinical use. We previously developed a ¹⁸F-labeled phosphonium cation, [¹⁸F]FPTP, that demonstrated sharply defined myocardial defects in a corresponding infarcted myocardium. The aim of this study was to compare the image properties of PET scans obtained using [¹⁸F]FPTP with those obtained using [¹³N]NH₃ in rat myocardial infarction models. Perfusion abnormality was analyzed in 17 segments of polar map images. The myocardium-to-liver and myocardium-to-lung ratios of [¹⁸F]FPTP were 10.48 and 2.65 times higher, respectively, than those of [¹³N]NH₃ in images acquired 30 min after tracer injection. The myocardial defect size measured by [¹⁸F]FPTP correlated more closely with the hypoperfused area measured by quantitative 2,3,5-triphenyltetrazolium chloride staining (r = 0.89, P < 0.01) than did [¹³N]NH₃ (r = 0.84, P < 0.01). [¹⁸F]FPTP might be useful as a replacement for the myocardial agent [¹³N]NH₃ in cardiac PET/CT applications.

Keywords:

Myocardial imaging agent; ¹⁸F-labeled phosphonium salt; [¹³N]ammonia; positron emission tomography (PET); myocardial infarction