Amino Acid Bound Surfactants: A New Synthetic Family of Polymeric Monoliths Opening Up Possibilities for Chiral Separations in Capillary Electrochromatography

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• 作者：Jun He ; Xiaochun Wang ; Mike Morill ; Shahab A. Shamsi
• 刊名：Analytical Chemistry
• 出版年：2012
• 出版时间：June 19, 2012
• 年：2012
• 卷：84
• 期：12
• 页码：5236-5242
• 全文大小：314K
• 年卷期：v.84,no.12(June 19, 2012)
• ISSN：1520-6882

文摘

By combining a novel chiral amino-acid surfactant containing an acryloyl amide tail, a carbamate linker, and a leucine headgroup of different chain lengths with a conventional cross-linker and a polymerization technique, a new 鈥渙ne-pot鈥?synthesis for the generation of amino-acid based polymeric monolith is realized. The method promises to open up the discovery of an amino-acid based polymeric monolith for chiral separations in capillary electrochromatography (CEC). The possibility of enhanced chemoselectivity for simultaneous separation of ephedrine and pseudoephedrine containing multiple chiral centers and the potential use of this amino-acid surfactant bound column for CEC and CEC coupled to mass spectrometric detection are demonstrated.