Palladium-Catalyzed Sulfination of Aryl and Heteroaryl Halides: Direct Access to Sulfones and Sulfonamides

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• 作者：Andrei Shavnya ; Steven B. Coffey ; Aaron C. Smith ; Vincent Mascitti
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：December 20, 2013
• 年：2013
• 卷：15
• 期：24
• 页码：6226-6229
• 全文大小：328K
• 年卷期：v.15,no.24(December 20, 2013)
• ISSN：1523-7052

文摘

A novel palladium-catalyzed sulfination of aryl and heteroaryl halides is described. This reaction operates under mild conditions and provides access to a wide range of aryl and heteroaryl sulfinates, a useful and versatile class of synthetic intermediates. Capitalizing on this sulfination reaction, one-pot protocols allowing direct access to sulfones and sulfonamides have also been developed. The practicality of these transformations is illustrated with the parallel synthesis of analogues of the drug Viagra.