Triterpenoids and Steroids from the Fruits of Melia toosendan and Their Cytotoxic Effects on Two Human Cancer Cell Lines
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- 作者：Shi-Biao Wu ; Jing-Jing Su ; Lian-Hui Sun ; Wen-Xuan Wang ; Yun Zhao ; Hui Li ; Sheng-Ping Zhang ; Guang-Hui Dai ; Chuan-Gui Wang ; Jin-Feng Hu
- 刊名：Journal of Natural Products
- 出版年：2010
- 出版时间：November 29, 2010
- 年：2010
- 卷：73
- 期：11
- 页码：1898-1906
- 全文大小：258K
- 年卷期：v.73,no.11(November 29, 2010)
- ISSN：1520-6025
文摘
Ten new triterpenoids, named meliasenins I−R (1−10), one new steroid (11), and 11 related known compounds (12−22) were isolated from fruits of Melia toosendan. The structures of the new compounds were established on the basis of spectroscopic methods, including 2D NMR techniques and mass spectrometry. The relative configuration of 1, (20R*,23E)-25-hydroperoxyeupha-7,23-diene-3β,16β-diol (meliasenin I), was confirmed by single-crystal X-ray diffraction analysis. All isolated triterpenoids (1−10, 12−15) and two steroids (11, 20) were tested for their cytotoxicity against U20S human osteosarcoma and MCF-7 human breast cancer cells using the MTT assay, and some of them were significantly cytotoxic (IC50 <10 μg/mL). The insecticidal properties of compounds 1−15 and 20 were also briefly evaluated.