Stereoselective Synthesis of d-5-Homo-4-selenoribose as a Versatile Intermediate for 4鈥?Selenonucleosides

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• 作者：Gyudong Kim ; Yoojin Choi ; Pramod K. Sahu ; Jinha Yu ; Shuhao Qu ; Dongjoo Lee ; Lak Shin Jeong
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：September 18, 2015
• 年：2015
• 卷：17
• 期：18
• 页码：4636-4639
• 全文大小：380K
• ISSN：1523-7052

文摘

Stereoselective synthesis of d-5-homo-4-selenoribose, serving as a versatile intermediate for the synthesis of 4鈥?selenonucleosides 12a鈥?b>c, was accomplished using Sharpless asymmetric epoxidation, regioselective cleavage of the 伪,尾-epoxide, and stereoselective reduction of the ketone as the key steps.