Spiromastixones A鈥揙, Antibacterial Chlorodepsidones from a Deep-Sea-Derived Spiromastix sp. Fungus

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• 作者：Siwen Niu ; Dong Liu ; Xinxin Hu ; Peter Proksch ; Zhongzhe Shao ; Wenhan Lin
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：April 25, 2014
• 年：2014
• 卷：77
• 期：4
• 页码：1021-1030
• 全文大小：356K
• 年卷期：v.77,no.4(April 25, 2014)
• ISSN：1520-6025

文摘

Fifteen new depsidone-based analogues named spiromastixones A鈥揙 (1鈥?b>15) were isolated from the fermentation broth of a deep-sea Spiromastix sp. fungus. Their structures were elucidated on the basis of extensive NMR and mass spectroscopic analysis in association with chemical conversion. Spiromastixones A鈥揙 are classified into two subtypes based on the orientation of ring C relative to ring A, while the n-propyl substituents on rings A and C are rarely seen in natural products. Most analogues are substituted by various numbers of chlorine atoms. All compounds exhibited significant inhibition against Gram-positive bacteria including Staphylococcus aureus, Bacillus thuringiensis, and Bacillus subtilis with MIC values ranging from 0.125 to 8.0 渭g/mL. In addition, compounds 6鈥?b>10 displayed potent inhibitory effects against methicillin-resistant bacterial strains of S. aureus (MRSA) and S. epidermidis (MRSE), while 10 also inhibited the growth of the vancomycin-resistant bacteria Enterococcus faecalis and E. faecium (VRE). The structure鈥揳ctivity relationships are discussed.