A Novel Method for the Preparation of 4-Arylimidazolones

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• 作者：Duane E. DeMong ; Irene Ng ; Michael W. Miller ; Andrew W. Stamford
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：June 7, 2013
• 年：2013
• 卷：15
• 期：11
• 页码：2830-2833
• 全文大小：273K
• 年卷期：v.15,no.11(June 7, 2013)
• ISSN：1523-7052

文摘

A series of 4-arylimidazolones have been accessed via late-stage, palladium-mediated arylation of acetone- and cyclohexanone-derived 4-chloroimidazolones. The 4-chloroimidazolones were prepared via a novel rearrangement of the corresponding imidazolone N-oxides. This communication serves as an expansion of chemistry originally developed for our glucagon receptor antagonist program.